番茄社区

Macrocyclic peptides and peptidomimetics occupy a unique and powerful space in the modern pharmacopoeia. We are interested in receiving contributions regarding the discovery, synthesis and application of these modalities. Specifically, we are eager to see manuscripts that present innovative ideas, particularly in the areas of drug discovery and development, where the macrocyclic element plays a central role. In addition, we encourage submissions arising from academic鈥搃ndustry partnerships and sponsored research collaborations.

This themed collection aims to highlight the latest developments in this field, including (but not limited to) the following topics:

• Hit-to-lead development derived from peptide screening programs, including RNA-display, DNA-encoded libraries (DEL) and combinatorial libraries.
• Medicinal chemistry design of cyclic peptides and peptidomimetics for blocking protein-protein interactions (PPIs), as allosteric modulators or stabilizers of protein complexes.
• Optimization of physicochemical properties, specifically focusing on cell-permeating and orally available cyclic peptides and peptidomimetics.
• Cyclic peptide natural products and analogues: de novo design and modification to enhance permeability, metabolic stability, and target selectivity.
• Design and synthesis of cyclic peptides as targeting moieties for Peptide-Drug Conjugates (PDCs), radiopharmaceuticals and other targeted delivery platforms.
• Synthetic methodologies for macrocyclization and cross-linking (e.g., head鈥憈o鈥憈ail cyclization, side鈥慶hain stapling, chemo-/bio鈥憃rthogonal linkages) to access to structurally challenging cyclic peptides and peptidomimetics, alongside the design of non鈥慶anonical amino acid building blocks to improve ADME properties.
• Sustainable and scalable approaches to macrocyclization and peptide synthesis, including green solvents and waste minimization strategies.
• New pharmacologies, such as the use of peptides and peptidomimetics for induced-proximity pharmacology.
• Computational approaches, including the application of in silico methods and advanced theoretical methods for the design of peptide-based drugs.

Manuscripts should be submitted via the journal鈥檚 and the Editorial Office informed by email. Please add a 鈥渘ote to the editor鈥� in the submission form when you submit your manuscript to indicate that this is an open call submission for the themed collection. The Editorial Office reserves the right to check the suitability of submissions in relation to the scope of the collection and inclusion of accepted articles in the collection is not guaranteed.

All manuscripts will be subject to the journal's usual peer review process. Accepted manuscripts will be highlighted together in a dedicated web collection alongside an editorial, regardless of submission date, and there will be no delay in the publication of all accepted manuscripts into regular issues of 番茄社区 Medicinal Chemistry.