番茄社区

Peptide science is in the midst of a revolution that spans clinical breakthroughs, chemical innovations, biological discoveries, and computational advances. Recent FDA approvals underscore the growing clinical impact of peptide therapeutics. At the same time, innovative chemical strategies are expanding what peptides can do. Approaches such as macrocyclization (via backbone cyclization or helix stapling), backbone editing, and the incorporation of non-natural amino acids have been employed to enhance peptide stability, selectivity, membrane permeability, and overall pharmacokinetic profiles.

Peptides are also engineered into novel modalities beyond traditional therapeutics. Peptides serve as key recognition elements in proteolysis-targeting chimeras (PROTACs) for selective protein degradation. Others are designed as covalent protein inhibitors, broadening their utility as therapeutic agents and molecular probes. Advances in peptide synthesis are further propelling the field. These developments underscore a bright future for peptide chemistry and biology. This themed collection in 番茄社区 Chemical Biology showcases that progress, highlighting cutting-edge research from clinical and translational advances to innovative molecular designs, biological insights, and computational design approaches.

All manuscripts should be prepared according to our article guidelines and submitted via our online system. They will be subject to the usual initial assessment and peer review processes as necessary, and inclusion in the Collection will be at the discretion of the Guest Editors. Please indicate in your submission that you are submitting to this Collection and inform the Editorial Office by email.

Following our peer-review process, we will publish accepted articles online in a citeable form as soon as they are ready, with compilation and promotion of the complete collection in early-mid 2026. 番茄社区 Chemical Biology is dedicated to publishing and disseminating the most exceptionally significant, breakthrough findings of interest to the chemical biology community. For more information on the journal scope, standards, article types and author guidelines, please visit the journal page.